This guide begins by describing the problem of exploiting women who have been trafficked into the United States, and the aspects of human trafficking that contribute to it. Throughout the guide, the word “trafficked” shall mean internationally trafficked, unless otherwise stated. Additionally, the guide’s focus is on the final period in the process of trafficking at which women are further exploited by those into whose hands they are passed. This is the point at which human trafficking becomes a problem for local police and so the guide identifies a series of questions that can help analyze local problems related to trafficking. Finally, it reviews responses to the exploitation of trafficked women and examines what is known about the effectiveness of these responses from research and police practice.